2024, Vol. 6, Issue 5, Part B

Background: Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women that causes irregular periods and excess male hormones (androgens) leading to symptoms such as acne and unwanted hair growth. Although previous research hinted at the potential of vitamin E to improve PCOS, this study aimed to explore its effectiveness in managing symptoms among Iraqi women.

Methods: A cross-sectional study was conducted and 73 women with PCOS from two hospitals in Baghdad were recruited between April and October 2023. They collected data through interviews, questionnaires, and physical measurements to assess the characteristics of the participants, the symptoms of PCOS, and the body composition (BMI). Medical records provided information on the duration of symptoms and lifestyle changes. Blood tests evaluated hormone levels, blood sugar control (HbA1c), and cholesterol profiles. Finally, they compared the health outcomes of women taking vitamin E supplements with those who did not.

Results: More than 30% of the participants incorporated vitamin E into their PCOS management. In particular, most were overweight or obese. Interestingly, vitamin E supplementation was associated with a significant decrease in androgenic symptoms such as hair loss (p=0.017), weight gain (p = 0.04), and acne (p=0.016). Furthermore, women taking vitamin E had lower levels of hormones associated with PCOS, including luteinizing hormone (LH, p<0.001), prolactin (p<0.001), and testosterone (p=0.015). This suggests potential benefits for hormonal regulation. Furthermore, HbA1c, a marker of long-term blood sugar control, was significantly lower in the vitamin E group (p=0.005). However, no significant impact on cholesterol, triglycerides, or fasting blood sugar levels was observed.

Conclusion: This study found promising evidence for vitamin E supplementation to manage PCOS symptoms. Women taking vitamin E reported less frequent androgenic symptoms such as hair loss, weight gain, and acne. Furthermore, their blood work showed improved hormonal profiles and better long-term blood sugar control. However, no significant effects were observed on blood cholesterol, triglycerides, or immediate blood sugar levels.